An Unbiased View of pkrrating
The interfacial residues are remarkably conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations support a model where activating RNA serves as a scaffold to bind several PKR monomers, escalating the